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<html><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><title>SEC FORM 
            4</title><style type="text/css">
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      </style></head><body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4"><tr><td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td><td rowspan="2" width="60%" valign="middle" align="center"><span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span></td><td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box"><tr><td class="FormTextC">OMB APPROVAL</td></tr><tr><td><table width="100%" border="0" summary="OMB Interior Box"><tr><td class="SmallFormText" colspan="3">OMB Number:</td><td class="SmallFormTextR">3235-0287</td></tr><tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr><tr><td class="SmallFormText" colspan="3">hours per response:</td><td class="SmallFormTextR">0.5</td></tr></table></td></tr></table></td></tr><tr valign="middle"><td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td><td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td></tr><tr valign="middle"><td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td><td class="SmallFormText">Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10. </td></tr></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><tr><td rowspan="4" width="35%" valign="top"><span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001559712">Pedersen Leif E</a></td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" class="MedSmallFormText">(Last)</td><td width="33%" class="MedSmallFormText">(First)</td><td width="33%" class="MedSmallFormText">(Middle)</td></tr></table><table border="0" width="100%"><tr><td><span class="FormData">C/O CERTARA, INC.</span></td></tr><tr><td><span class="FormData">4 RADNOR CORPORATE CENTER, SUITE 350</span></td></tr></table><hr width="98%"><span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr><td width="33%"><span class="FormData">RADNOR</span></td><td width="33%"><span class="FormData">
				PENNSYLVANIA
			</span></td><td width="33%"><span class="FormData">19087</span></td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" class="MedSmallFormText">(City)</td><td width="33%" class="MedSmallFormText">(State)</td><td width="33%" class="MedSmallFormText">(Zip)</td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" colspen="3"><span class="FormData">UNITED STATES</span></td></tr></table><hr width="98%"><span class="MedSmallFormText">(Country)</span></td><td width="35%" valign="top"><span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001827090">Certara, Inc.</a>
     [ <span class="FormData">CERT</span> ]
   </td><td rowspan="2" valign="top"><span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%"><tr><td width="15%" align="center"></td><td width="35%" class="MedSmallFormText">Director</td><td width="15%" align="center"></td><td width="35%" class="MedSmallFormText">10% Owner</td></tr><tr><td align="center"><span class="FormData">X</span></td><td class="MedSmallFormText">Officer (give title below)</td><td align="center"></td><td class="MedSmallFormText">Other (specify below)</td></tr><tr><td width="15%" align="center"></td><td width="35%" align="left" style="color: blue">PRESIDENT, CHIEF COMMERCAL OFF</td><td width="15%" align="center"></td><td width="35%" align="left" style="color: blue"></td></tr></table></td></tr><tr><td valign="top"><span class="MedSmallFormText">2a. Foreign Trading Symbol
		 <br></span></td></tr><tr><td valign="top"><span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">05/11/2026</span></td><td valign="top" rowspan="2"><span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%"><tr><td width="15%" align="center"><span class="FormData">X</span></td><td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td></tr><tr><td width="15%" align="center"></td><td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td></tr></table></td></tr><tr><td valign="top" rowspan="1"><span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br><br></td></tr></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><thead><tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr><tr><th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th><th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th><th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th><th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th><th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th><th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th></tr><tr><th width="4%" align="center" class="SmallFormText">Code</th><th width="3%" align="center" class="SmallFormText">V</th><th width="8%" align="center" class="SmallFormText">Amount</th><th width="5%" align="center" class="SmallFormText">(A) or (D)</th><th width="6%" align="center" class="SmallFormText">Price</th></tr></thead></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><thead><tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC"><b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b></th></tr><tr><th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th><th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th><th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th><th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th><th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th><th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th></tr><tr><th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th><th width="4%" valign="bottom" align="center" class="SmallFormText">V</th><th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th><th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th><th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th><th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th><th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th><th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th></tr></thead><tbody><tr><td align="left"><span class="SmallFormData">Performance Stock Units</span></td><td align="center"><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">05/11/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">D</span></td><td align="center"></td><td align="center"></td><td align="center"><span class="SmallFormData">68,348</span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">68,348</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"><span class="SmallFormData"></span></td></tr><tr><td align="left"><span class="SmallFormData">Performance Stock Units</span></td><td align="center"><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">05/11/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">A</span></td><td align="center"></td><td align="center"><span class="SmallFormData">68,348</span></td><td align="center"></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">68,348</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">68,348</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"><span class="SmallFormData"></span></td></tr><tr><td align="left"><span class="SmallFormData">Restricted Stock Units</span></td><td align="center"><span class="FootnoteData"><sup>(2)</sup></span></td><td align="center"><span class="SmallFormData">05/11/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">A</span></td><td align="center"></td><td align="center"><span class="SmallFormData">74,074</span></td><td align="center"></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(2)</sup></span></td><td align="center"><span class="SmallFormData">04/01/2029</span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">74,074</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">74,074</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"><span class="SmallFormData"></span></td></tr><tr><td align="left"><span class="SmallFormData">Performance Stock Units</span></td><td align="center"><span class="FootnoteData"><sup>(3)</sup></span></td><td align="center"><span class="SmallFormData">05/11/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">A</span></td><td align="center"></td><td align="center"><span class="SmallFormData">111,111</span></td><td align="center"></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">111,111</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">111,111</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"><span class="SmallFormData"></span></td></tr></tbody></table><table border="0" width="100%"><tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr><tr><td class="FootnoteData">1. Each Certara, Inc. ("Company") performance stock unit ("PSU") was granted on May 20, 2025, pursuant to the terms of the 2025 Long-Term Incentive Plan for Company executives  approved by the Compensation Committee of the Company's Board of Directors, under the Certara 2020 Incentive Plan (the "2020 Incentive Plan"). Each PSU represents a conditional right to receive one share of Company common stock. The reporting person will be entitled to receive a number of shares between 0% and 200% of the target amount reported based on the Company's performance against certain total shareholder return thresholds through the period ending on March 31, 2028.</td></tr><tr><td class="FootnoteData">2. Each restricted stock unit ("RSU") was granted on May 11, 2026, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent. The RSUs will vest and settle in three equal installments on April 1, 2027, April 1, 2028, and April 1, 2029.</td></tr><tr><td class="FootnoteData">3. Each Company PSU was granted on May 11, 2026, pursuant to the terms of the 2026 Long-Term Incentive Plan for Company executives approved by the Compensation Committee of the Company's Board of Directors, under the 2020 Incentive Plan. Each PSU represents a conditional right to receive one share of Company common stock. The reporting person will be entitled to receive a number of shares between 0% and 200% of the target amount reported based on the Company's performance against certain total shareholder return thresholds through the period ending on March 31, 2029.</td></tr></table><table width="100%" border="0"><tr><td width="60%"></td><td width="20%"><u><span class="FormData">/s/ Daniel D. Corcoran, as Attorney--in-Fact for Leif E. Pedersen</span></u></td><td width="20%"><u><span class="FormData">05/13/2026</span></u></td></tr><tr><td></td><td class="MedSmallFormText">** Signature of Reporting Person</td><td class="MedSmallFormText">Date</td></tr><tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr><tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr><tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr><tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr><tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr><tr><td colspan="3" class="MedSmallFormText"><b>* Form 4: SEC 1474 (03-26)</b></td></tr></table></body></html>
