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            4</title><style type="text/css">
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      </style></head><body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4"><tr><td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td><td rowspan="2" width="60%" valign="middle" align="center"><span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span></td><td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box"><tr><td class="FormTextC">OMB APPROVAL</td></tr><tr><td><table width="100%" border="0" summary="OMB Interior Box"><tr><td class="SmallFormText" colspan="3">OMB Number:</td><td class="SmallFormTextR">3235-0287</td></tr><tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr><tr><td class="SmallFormText" colspan="3">hours per response:</td><td class="SmallFormTextR">0.5</td></tr></table></td></tr></table></td></tr><tr valign="middle"><td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td><td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td></tr><tr valign="middle"><td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td><td class="SmallFormText">Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10. </td></tr></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><tr><td rowspan="4" width="35%" valign="top"><span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001559779">Egholm Michael</a></td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" class="MedSmallFormText">(Last)</td><td width="33%" class="MedSmallFormText">(First)</td><td width="33%" class="MedSmallFormText">(Middle)</td></tr></table><table border="0" width="100%"><tr><td><span class="FormData">C/O STANDARD BIOTOOLS INC.</span></td></tr><tr><td><span class="FormData">50 MILK STREET, 10TH FLOOR</span></td></tr></table><hr width="98%"><span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr><td width="33%"><span class="FormData">BOSTON</span></td><td width="33%"><span class="FormData">
				MASSACHUSETTS
			</span></td><td width="33%"><span class="FormData">02109</span></td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" class="MedSmallFormText">(City)</td><td width="33%" class="MedSmallFormText">(State)</td><td width="33%" class="MedSmallFormText">(Zip)</td></tr></table><hr width="98%"><table border="0" width="100%"><tr><td width="33%" colspen="3"><span class="FormData">UNITED STATES</span></td></tr></table><hr width="98%"><span class="MedSmallFormText">(Country)</span></td><td width="35%" valign="top"><span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001162194">STANDARD BIOTOOLS INC.</a>
     [ <span class="FormData">LAB</span> ]
   </td><td rowspan="2" valign="top"><span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%"><tr><td width="15%" align="center"><span class="FormData">X</span></td><td width="35%" class="MedSmallFormText">Director</td><td width="15%" align="center"></td><td width="35%" class="MedSmallFormText">10% Owner</td></tr><tr><td align="center"><span class="FormData">X</span></td><td class="MedSmallFormText">Officer (give title below)</td><td align="center"></td><td class="MedSmallFormText">Other (specify below)</td></tr><tr><td width="15%" align="center"></td><td width="35%" align="left" style="color: blue">President &amp; CEO</td><td width="15%" align="center"></td><td width="35%" align="left" style="color: blue"></td></tr></table></td></tr><tr><td valign="top"><span class="MedSmallFormText">2a. Foreign Trading Symbol
		 <br></span></td></tr><tr><td valign="top"><span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">03/20/2026</span></td><td valign="top" rowspan="2"><span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%"><tr><td width="15%" align="center"><span class="FormData">X</span></td><td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td></tr><tr><td width="15%" align="center"></td><td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td></tr></table></td></tr><tr><td valign="top" rowspan="1"><span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br><br></td></tr></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><thead><tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr><tr><th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th><th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th><th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th><th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th><th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th><th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th></tr><tr><th width="4%" align="center" class="SmallFormText">Code</th><th width="3%" align="center" class="SmallFormText">V</th><th width="8%" align="center" class="SmallFormText">Amount</th><th width="5%" align="center" class="SmallFormText">(A) or (D)</th><th width="6%" align="center" class="SmallFormText">Price</th></tr></thead><tbody><tr><td align="left"><span class="FormData">Common Stock</span></td><td align="center"><span class="FormData">03/20/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">A</span></td><td align="center"></td><td align="center"><span class="FormData">1,042,373</span><span class="FootnoteData"><sup>(1)</sup></span></td><td align="center"><span class="FormData">A</span></td><td align="center"><span class="FormText">$</span><span class="FormData">0</span></td><td align="center"><span class="FormData">6,594,083</span></td><td align="center"><span class="FormData">D</span></td><td align="left"></td></tr><tr><td align="left"><span class="FormData">Common Stock</span></td><td align="center"><span class="FormData">04/06/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">M</span></td><td align="center"></td><td align="center"><span class="FormData">196,513</span></td><td align="center"><span class="FormData">A</span></td><td align="center"><span class="FormText">$</span><span class="FormData">0</span></td><td align="center"><span class="FormData">6,790,596</span></td><td align="center"><span class="FormData">D</span></td><td align="left"></td></tr><tr><td align="left"><span class="FormData">Common Stock</span></td><td align="center"><span class="FormData">04/06/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">F</span></td><td align="center"></td><td align="center"><span class="FormData">95,014</span><span class="FootnoteData"><sup>(2)</sup></span></td><td align="center"><span class="FormData">D</span></td><td align="center"><span class="FormText">$</span><span class="FormData">0.908</span></td><td align="center"><span class="FormData">6,695,582</span></td><td align="center"><span class="FormData">D</span></td><td align="left"></td></tr></tbody></table><table width="100%" border="1" cellspacing="0" cellpadding="4"><thead><tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC"><b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b></th></tr><tr><th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th><th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th><th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th><th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th><th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th><th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th><th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th><th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th></tr><tr><th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th><th width="4%" valign="bottom" align="center" class="SmallFormText">V</th><th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th><th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th><th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th><th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th><th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th><th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th></tr></thead><tbody><tr><td align="left"><span class="SmallFormData">Stock Option (Right to buy)</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0.9846</span></td><td align="center"><span class="SmallFormData">03/20/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">A</span></td><td align="center"></td><td align="center"><span class="SmallFormData">2,345,340</span></td><td align="center"></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span></td><td align="center"><span class="SmallFormData">03/20/2036</span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">2,345,340</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">2,345,340</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"></td></tr><tr><td align="left"><span class="SmallFormData">Restricted Stock Units</span></td><td align="center"><span class="FootnoteData"><sup>(4)</sup></span></td><td align="center"><span class="SmallFormData">04/06/2026</span></td><td align="center"></td><td align="center"><span class="SmallFormData">M</span></td><td align="center"></td><td align="center"></td><td align="center"><span class="SmallFormData">196,513</span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(5)</sup></span></td><td align="center"><span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(5)</sup></span></td><td align="center"><span class="SmallFormData">Common Stock</span></td><td align="center"><span class="FormData">196,513</span></td><td align="center"><span class="SmallFormText">$</span><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">0</span></td><td align="center"><span class="SmallFormData">D</span></td><td align="left"></td></tr></tbody></table><table border="0" width="100%"><tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr><tr><td class="FootnoteData">1. Represents restricted stock units ("RSUs") that vest over four years, with 1/16 of the RSUs vesting on May 20, 2026 and the remaining RSUs vesting in equal quarterly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date. Each RSU represents the right to receive one share of common stock upon vesting.</td></tr><tr><td class="FootnoteData">2. The shares were withheld from the reporting person to satisfy the tax withholding obligations that arose upon the vesting of RSUs granted to the reporting person on April 4, 2022, which grant was originally reported on Form 4 filed with the U.S. Securities and Exchange Commission on April 6, 2022.</td></tr><tr><td class="FootnoteData">3. The Option becomes exercisable as to 1/16th of the underlying shares on May 20, 2026, with the remaining shares vesting in equal quarterly installments thereafter, subject to the Reporting Person's continued service through the applicable vesting date.</td></tr><tr><td class="FootnoteData">4. Each RSU represents the contingent right to receive one share of the Issuer's common stock.</td></tr><tr><td class="FootnoteData">5. On April 4, 2022, the Reporting Person was granted 786,049 RSUs, vesting in four equal annual installments beginning on April 4, 2023.</td></tr></table><table width="100%" border="0"><tr><td width="60%"></td><td width="20%"><u><span class="FormData">/s/ Michael Egholm by Hanjoon Alex Kim,  Attorney-in-Fact</span></u></td><td width="20%"><u><span class="FormData">04/08/2026</span></u></td></tr><tr><td></td><td class="MedSmallFormText">** Signature of Reporting Person</td><td class="MedSmallFormText">Date</td></tr><tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr><tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr><tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr><tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr><tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr><tr><td colspan="3" class="MedSmallFormText"><b>* Form 4: SEC 1474 (03-26)</b></td></tr></table></body></html>
