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<title>SEC FORM 
            3</title>
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<body>SEC Form 3 
   <table width="100%" border="0" cellspacing="0" cellpadding="4"><tr>
<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 3</td>
<td rowspan="1" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="1" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0104</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
</tr></table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="30%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0002086031">Riffner Laura C</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">1319 MARQUETTE DRIVE</span></td></tr>
<tr><td><span class="FormData"></span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">ROMEOVILLE</span></td>
<td width="33%"><span class="FormData">IL</span></td>
<td width="33%"><span class="FormData">60446</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td rowspan="3" width="15%" valign="top">
<span class="MedSmallFormText">2. Date of Event Requiring Statement
         (Month/Day/Year)</span><br><span class="FormData">09/03/2025</span>
</td>
<td valign="top" colspan="2">
<span class="MedSmallFormText">3. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0000883107">SOLESENCE, INC.</a>
     [ <span class="FormData">SLSN</span> ]
   </td>
</tr>
<tr>
<td rowspan="2" width="30%" valign="top">
<span class="MedSmallFormText">4. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"><span class="FormData">X</span></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue">Chief Financial Officer</td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
<td valign="top">
<span class="MedSmallFormText">5. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td></tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4"><thead>
<tr><th width="100%" valign="top" colspan="4" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Beneficially Owned</b></th></tr>
<tr>
<th width="44%" valign="top" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      4)
   </th>
<th width="19%" valign="top" align="left" class="MedSmallFormText">2. 
      Amount of Securities Beneficially Owned (Instr. 
      4)
   </th>
<th width="11%" valign="top" align="left" class="MedSmallFormText">3. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      5)
   </th>
<th width="26%" valign="top" align="left" class="MedSmallFormText">4. Nature of Indirect Beneficial Ownership (Instr. 
      5)
   </th>
</tr>
</thead></table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="8" align="center" class="FormTextC">
<b>Table II - Derivative Securities Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="35%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Derivative Security (Instr. 
      4)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="MedSmallFormText">2. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="26%" valign="top" colspan="2" align="left" class="MedSmallFormText">3. Title and Amount of Securities Underlying Derivative Security (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="MedSmallFormText">4. Conversion or Exercise Price of Derivative Security
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="MedSmallFormText">5. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      5)
   </th>
<th width="15%" valign="top" rowspan="2" align="left" class="MedSmallFormText">6. Nature of Indirect Beneficial Ownership (Instr. 
      5)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="MedSmallFormText">Date Exercisable</th>
<th width="5%" valign="bottom" align="center" class="MedSmallFormText">Expiration Date</th>
<th width="20%" valign="bottom" align="center" class="MedSmallFormText">Title</th>
<th width="6%" valign="bottom" align="center" class="MedSmallFormText">Amount or Number of Shares</th>
</tr>
</thead>
<tbody><tr>
<td align="left"><span class="FormData">Common Stock (right to purchase</span></td>
<td align="center">
<span class="SmallFormData">09/03/2026</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="SmallFormData">09/03/2032</span></td>
<td align="center"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">60,000</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">3.5</span>
</td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr></tbody>
</table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. Subject to certain restrictions, beginning on this date, options vest in three equal annual installments.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData">Ms. Riffner began employment with Solesence, Inc. on September 3, 2025.  This option grant was effective that day, with the strike price based upon the closing NASDAQ market price that same day.  We did not have Ms. Riffner's CIK number available to complete this filing timely, this was compounded by technical issues relating to the adoption of EDGAR Next.</td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">/s/ Laura C. Riffner</span></u></td>
<td width="20%"><u><span class="FormData">10/06/2025</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  5

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
</table>
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