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November 22, 2010		Arthur B. Price T +1 617 951 7402
		F +1 617 235 7341
		[email protected]

VIA EDGAR

Securities and Exchange Commission
Division of Corporation Finance
100 F Street
Washington, D.C. 20549
Attention: Jeffrey P. Riedler

Re:

RXi Pharmaceuticals Corporation Form 10-K for the Fiscal Year Ended December 31, 2009 Filed March 31, 2010 Schedule 14A filed April 23, 2010 Form 10-Q for the Quarterly Period Ended March 31, 2010 Filed May 17, 2010 File No. 001-33958

Ladies and Gentlemen:

On behalf of RXi Pharmaceuticals Corporation (the “Company”), we wish to inform you that we will respond by December 15, 2010 to the Staff’s letter to the Company dated November 10, 2010.

Very truly yours,

/s/ Arthur B. Price

Arthur B. Price

cc:

Laura Crotty, SEC Noah D. Beerman, RXi Pharmaceuticals Corporation Amy Tata, RXi Pharmaceuticals Corporation Marc A. Rubenstein, Ropes & Gray LLP